Philadelphia Eagles (2-2) vs. Jacksonville Jaguars (3-1) in London
Sunday, 9:30 a.m. ET
FanDuel odds: Jaguars -7.5, Total 41.5
Series Rewind: Jacksonville won the first three games in this series but Philadelphia has won the last five to claim a 5-3 lead. That includes a 2018 game in London which the Eagles won 24-18.
The Eagles head across the pond with a new-look offense of sorts after offensive tackle Lane Johnson retired and two-time Pro Bowl center Cam Jurgens was traded this week, and running backs Saquon Barkley (hamstring) and Tank Bigsby (core) are expected to be sidelined. Will Shipley could step into a feature role at running back. Since he was drafted in the fourth round in 2024, he has largely been a kick returner, with just 59 carries for 182 yards and no touchdowns in 35 games (one start). Philadelphia elevated Dameon Pierce from its practice squad Wednesday, giving the position group a former starter who rushed for 1,684 yards and eight TDs over the last four seasons. The Jaguars, who enter off consecutive wins over New England and Cincinnati, boast the third-best rushing defense in the NFL (74.3 yards allowed per game) and gave up just 23 rushing yards last week to the Cincinnati Bengals. Jacksonville also has a league-best plus-6 turnover margin (eight takeaways, two giveaways) and is second in scoring defense at 13.3 points per game. With a win over the Eagles, the Jaguars, who will stay in London through next Sunday’s game against the Houston Texans, would be off to a second 4-1 start in as many seasons under coach Liam Coen. Before last season, they hadn’t started 4-1 or better since 2007.
New York Giants (3-1) at Washington Commanders (1-3)
Sunday, 1 p.m. ET
FanDuel odds: Commanders -3.5, Total 42.5
Series Rewind: Washington has won the past four meetings, QB Jayden Daniels is 3-0 against the Giants and Commanders coach Dan Quinn is 6-0 all-time against New York.
Daniels is back in the lineup after a two-game absence caused by another injury to his left (non-throwing) elbow. The Giants’ pass rush is diminished without Brian Burns and will be further compromised by Daniels’ mobility. The Giants are deploying linebacker Arvell Reese in unique ways. The first-round pick out of Ohio State will share the field with former Buckeyes teammate Sonny Styles, Washington’s first-round rookie. Each had an interception in Week 4. Daniels has played just six quarters this season. He reached 70 rushing yards in first half of his team’s Week 2 loss to the Dallas Cowboys before he was injured. The Giants are working with Jameis Winston as their QB1 after Jaxson Dart suffered a season-ending knee injury. Winston and wide receiver Malik Nabers connected for a passing touchdown last week. It was Nabers’ first TD of the season.
Cincinnati Bengals (2-2) at Miami Dolphins (0-4)
Sunday, 1 p.m. ET
FanDuel odds: Bengals -6.5, Total 43.5
Series Rewind: Miami leads the all-time series 18-9 but Cincinnati has won the last two and four of the last six, including a 45-21 win last December in Miami.
Cincinnati’s 2-0 start has been spoiled by consecutive losses to the Pittsburgh Steelers and the Jaguars. A matchup against the winless Dolphins provides a chance to snap that skid, but the potential absences of star receivers Ja’Marr Chase (concussion) and Tee Higgins (groin/neck) would test an offense that ranks fifth in the NFL with 277.5 passing yards per game but is last in the AFC and 31st in the league with 74.3 rushing yards per contest. Bengals quarterback Joe Burrow ranks fifth in the league with 292.8 yards passing per game and a 71.3% completion percentage, but he could be forced to rely on rookie wideout Colbie Young, among others. The Dolphins have shown improvement on defense the past two weeks in losses to the Kansas City Chiefs and Minnesota Vikings. They had not mustered a sack through their first three games, but that changed dramatically last week when they took down Minnesota’s Kyler Murray four times. They also kept the Vikings out of the end zone, but Will Reichard’s five field goals helped Minnesota escape with a 15-10 win. Miami also appears to have found an impact rookie in linebacker Jacob Rodriguez, who ranks second in the NFL with 46 tackles. The Dolphins lost lead running back De’Von Achane to a torn ACL in Week 3, but his replacement, Ollie Gordon, rushed for 100 yards and a touchdown on nine carries last week.
Cleveland Browns (3-1) at New York Jets (1-3)
Sunday, 1 p.m. ET
FanDuel odds: Jets -1.5, Total 39.5
Series Rewind: This is a balanced series, in which Cleveland narrowly leads 16-15 and the teams have split their last six meetings. They also faced off last November in East Rutherford, N.J., and the Jets took home a 27-20 victory.
Indianapolis Colts (2-2) at Pittsburgh Steelers (2-2)
Sunday, 1 p.m. ET
FanDuel: Steelers -2.5. Total: 44.5
Series Rewind: Pittsburgh registered a 27-20 home win over the Colts last season when it held running back Jonathan Taylor to 45 yards on 14 carries. Indianapolis had won the previous two meetings after the Steelers dominated before that with eight consecutive victories.
The surly version of quarterback Aaron Rodgers has had to time to calm down with Pittsburgh being off last weekend. Rodgers was visibly disappointed during a 27-24 road loss to the Browns on Oct. 1 and had a tense sideline exchange with coach Mike McCarthy. Rodgers saw his emotional displays as positives, and McCarthy saw similar theatrics many times while coaching Rodgers for 13 seasons (2006-18) with the Green Bay Packers. Rodgers has 999 passing yards and seven touchdowns against four interceptions through four games, but running back Jaylen Warren has arguably been Pittsburgh’s top offensive performer with 309 rushing yards, which ranks ninth in the NFL. Linebacker T.J. Watt is tied for third in the NFL with 4.5 sacks and remains as disruptive as ever. The Colts are coming off a 30-13 rout of the Washington Commanders in London, but the victory was overshadowed by owner Carlie Irsay-Gordon’s routine of hanging out on the sideline and taking notes, including charting plays. Taylor rushed for 95 yards and two touchdowns on 20 carries. It was his third game with more than 90 yards and his third game with two rushing scores. He ranks third in the NFL with 353 rushing yards and is 49 yards shy of 8,000 for his career. Quarterback Daniel Jones has thrown more interceptions (four) than touchdowns (three) this season. Defensive end DeForest Buckner is off to a strong start with three sacks to raise his career total to 74.5.
Chicago Bears (3-1) at Green Bay Packers (2-2)
Sunday, 1 p.m. ET
FanDuel odds: Bears -1.5, Total 45.5
Series Rewind: The NFL’s oldest rivalry (started in 1921) renews at Lambeau Field, where Green Bay prevailed in Week 14 last season. Chicago had the last laugh with victories at home in Week 16 and the wild-card round.
Each of the past six matches between the NFC North rivals, including the playoffs, has been a one-score game (decided by eight or fewer points). Chicago enters this week’s clash with the NFL’s best offense (429.0 yards per game) and top ground game (196.3 per contest). Green Bay is at the other end of the spectrum, with the NFL’s most anemic rushing attack (58.0 per game) and the fifth-fewest points (73). The Bears have won three games with three different starting quarterbacks. Tyson Bagent will make his second straight start for the injured Caleb Williams. Kyle Monangai ran for 146 yards in last week’s win against the Jets, scoring two rushing touchdowns — two more than the Packers have this season — but will miss Sunday’s game with a turf toe injury. Green Bay’s Jordan Love is one of four QBs with at least two TD passes in four consecutive games this season. Christian Watson leads the Packers with four touchdown catches, and he scored three times in three meetings with the Bears last season. Packers coach Matt LaFleur is 6-1 against Chicago at home.
Las Vegas Raiders (3-1) at New England Patriots (2-2)
Sunday, 1 p.m. ET
FanDuel odds: Patriots -3.5, Total 44.5
Series Rewind: The Raiders beat the Patriots 20-13 in Week 1 of the 2025 season to extend their winning streak over New England to three games.
Kirk Cousins has found new life in Las Vegas, even without a bona fide No. 1 receiver. Brock Bowers and Michael Mayer give the Raiders a strong tandem at tight end. Bowers missed the first two games of the season with a knee injury, but he caught 10 passes for 116 yards and a touchdown in a Week 3 victory over the New Orleans Saints and had six receptions for 86 yards and a TD in a loss to the Kansas City Chiefs last week. The Raiders and Detroit Lions are the only NFL teams that have scored at least 26 points in every game this season. The Patriots have not looked like the team that represented the AFC in the Super Bowl last season. They lost their opener to the Seahawks, for whom current Las Vegas coach Klint Kubiak served last season as play-caller and offensive coordinator. Given the number of injuries the Patriots have faced on defense, the pressure remains on for quarterback Drake Maye to put points on the board. The 2025 MVP runner-up showed life last week after throwing six interceptions and one touchdown pass in the first three games of the season. Maye was named AFC Offensive Player of the Week after completing 22 of 37 passes for 269 yards and three touchdowns in a 29-26 road victory over the Buffalo Bills in Orchard Park, N.Y. He also rushed for 54 yards on eight carries.
Denver Broncos (2-2) at Los Angeles Chargers (0-4)
Sunday, 4:05 p.m. ET
FanDuel odds: Broncos -3.5. Total: 42.5
Series Rewind: Denver recorded a 19-3 victory in the teams’ second meeting last season to halt a three-game slide against the Chargers. Justin Herbert didn’t play with the playoffs on the horizon, and neither team scored an offensive touchdown. The Broncos have won five of the past six meetings in Southern California.
Both offenses have underperformed. Denver has scored 20 or fewer points in three of its four games and ranks 27th in scoring offense (18.5 points per game) and 28th in total offense (280.3 yards per game). It gained 296 yards in last week’s 24-14 road loss to the San Francisco 49ers. Coach Sean Payton is taking over the play-calling duties from offensive coordinator Davis Webb, hoping to provide a spark and not so subtly saying, “This isn’t championship football.” Quarterback Bo Nix passed for 214 yards and one score against the 49ers. While Webb lost some of his duties, the Chargers are sticking with first-year offensive coordinator Mike McDaniel despite a poor first four games. The Chargers rank 29th in scoring (16.8 points per game) and have scored 16 or fewer points in three of four games. Herbert hasn’t mixed well with McDaniel; he has thrown for less than 200 yards twice and has more interceptions (six) than touchdown passes (four). In 2024, Herbert tossed a career-low three interceptions in 504 attempts. He has doubled that in just 119 throws this season while completing a career-worst 59.7% of his passes. On defense, pass rusher Khalil Mack has three sacks to raise his career total to 116. Safety Derwin James (hamstring) hasn’t practiced this week and could miss his second straight game. Broncos cornerback Patrick Surtain (ankle) missed consecutive practices and his status is still to be firmed up. Denver linebacker Alex Singleton leads the NFL with 47 tackles. He had 14 against the 49ers, his second-highest output of the season.
Detroit Lions (2-2) at Arizona Cardinals (1-3)
Sunday, 4:25 p.m. ET
FanDuel odds: Lions -5.5, Total 54.5
Series Rewind: The Lions are 5-0-1 in the past six meetings between the teams. Detroit most recently came to Arizona in September 2024 and handed the Cardinals a 20-13 defeat, with quarterback Jared Goff throwing for 199 yards and two touchdowns.
Points? We have points. The Lions rank 31st in the NFL in scoring defense, allowing 31.8 points per game, and last in passing defense at 304.0 yards per contest. The Cardinals (1-3) rank 29th in scoring defense, allowing 29.3 points per game. Arizona has lost three straight while surrendering at least 31 points in each defeat. Quarterback Jacoby Brissett should have open passing lanes as the Lions are still likely to be without starting safeties Brian Branch and Kerby Joseph. Branch returned to practice Wednesday for the first time since tearing his Achilles last December, but he is not ready for game action. Goff has yet to throw an interception in 161 pass attempts this season while tossing nine touchdown passes. Wide receiver Amon-Ra St. Brown and running back Jahmyr Gibbs rank in the NFL’s top 10 in receiving and rushing yards, respectively. St. Brown has recorded five touchdown catches and Gibbs five rushing touchdowns. While Brissett will likely have receivers open downfield, will he have time to find them? The Cardinals received bad news this week regarding the offensive line: starting left tackle Paris Johnson Jr. tore his left biceps in the team’s 36-24 loss to the New York Giants last week. Johnson, a former sixth overall draft pick, has 47 career starts in three-plus NFL seasons.
San Francisco 49ers (4-0) at Seattle Seahawks (3-1)
Sunday, 4:25 p.m. ET
FanDuel odds: Seahawks -3, Total 46.5
Series Rewind: This is a rematch of last season’s divisional playoff game at Lumen Field, where the Seahawks stormed to a 41-6 win. Rashid Shaheed returned the opening kickoff 95 yards for a touchdown, and Seattle was off and running from there.
The 49ers are 4-0 for the fourth time since 1990. Brock Purdy leads the NFL with a 126.2 passer rating and can become just the fifth QB this century with multiple touchdown passes and a triple-digit passer rating in each of his team’s first five games (Tom Brady, Peyton Manning, Aaron Rodgers and Russell Wilson). Christian McCaffrey has gained 100-plus yards from scrimmage in seven of his last eight games against the Seahawks. Tight end George Kittle is looking for his fourth straight game with a TD catch and has scored in three of his last four meetings with Seattle. The Seahawks counter with the NFL’s No. 1 defense (246.8 yards allowed per game) and No. 1 pass defense (144.8 allowed per game). Jaxon Smith-Njigba leads the league with six touchdown receptions but has not found the end zone in six career regular-season clashes with the NFC West rival 49ers. Emanuel Wilson will carry the load again in the Seattle backfield after posting 120 scrimmage yards and two scores in last week’s win over the Chargers.
Baltimore Ravens (3-1) at Atlanta Falcons (2-2)
Sunday, 8:20 p.m. ET
FanDuel odds: Falcons -3.5, Total 43.5
Series Rewind: The Ravens have swept the last three meetings and haven’t lost to the Falcons since 2010. The last time they met was on Christmas Eve in 2022 when Baltimore won 17-9 at home without Lamar Jackson (knee).
Atlanta is looking for a third consecutive win in prime time after beating the Packers on Thursday night in Week 3 and the Saints on Monday night in Week 4. Michael Penix Jr. completed 73.3% of his passes in those wins, his first two starts since tearing his left ACL last November. All eyes will be on the running backs in this game: Atlanta’s Bijan Robinson (6,262) and Baltimore’s Derrick Henry (5,658) rank first and second in the NFL in scrimmage yards since 2023. Henry will be facing a defense that ranks No. 1 in the league against the run, allowing just 48.3 yards per game. If the Ravens are forced to throw, they may be doing it without Jackson. He missed all three practices this week while dealing with the ankle injury he suffered in last Sunday’s win over the Titans. Backup Tyler Huntley would make his 17th career start, and 12th for Baltimore, if the two-time MVP is unavailable. Baltimore is 2-0 on the road under first-year head coach Jesse Minter, with wins at Indianapolis in Week 1 and Dallas in Week 3.
Buffalo Bills (3-1) at Los Angeles Rams (2-2)
Monday, 8:15 p.m. ET
FanDuel odds: Rams -3.5. Total: 54.5
Series Rewind: The Rams registered a 44-42 home victory over the Bills in 2024. Josh Allen accounted for six touchdowns (three passing, three rushing). Buffalo won eight of the previous 10 games prior to that meeting.
The last two NFL MVPs get a chance to put on a show on the Monday night stage. Allen, the 2024 winner, has passed for 1,039 yards and six touchdowns against three interceptions this season. He has seven rushing TDs, tying Derrick Henry for most in the NFL. The Bills lead the NFL in scoring at 31.8 points per game. The Rams are second in total offense (417 yards per game), but that hasn’t led to points. Los Angeles is 19th in scoring (21.3 points per game). Matthew Stafford, the reigning MVP, has thrown for 1,189 yards and six touchdowns but also has been intercepted six times. Only the Patriots’ Drake Maye (seven) has thrown more. Star wideout Puka Nacua looked healthy in Los Angeles’ 24-20 win over the Philadelphia Eagles with nine catches for 125 yards. Davante Adams, who had 137 and 195 receiving yards over the previous two games, had just four catches for 32 yards against the Eagles. Kyren Williams had two rushing scores in the final 3:59 as the Rams put together a furious comeback. Buffalo dropped a 29-26 home decision to the Patriots last week when New England held a 73-54 edge in offensive plays. Allen had 4 rushing yards and a touchdown on five carries. He denied midweek that he was dealing with soreness. A more spry Allen is likely to be seen if Rams star Aaron Donald is pursuing him. Bills wideout DJ Moore (shoulder) is pushing to be on the field. Buffalo defensive tackle Ed Oliver (knee) also is ailing.