Houston Texans (1-4) vs. Jacksonville Jaguars (4-1) in London
Sunday, 9:30 a.m. ET
FanDuel odds: Jaguars -2.5. Total: 42.5.
Series Rewind: Houston is 3-1 in the past four meetings, which includes a 36-29 shootout in the most recent game last November.
Winners last week for the first time this season, the Texans cross the pond to take on the Jaguars trying to prevent the AFC South division gap from widening further. DeMeco Ryans was successful in his takeover of defensive playcalling last week with four sacks and consistent pressure on Titans quarterback Cam Ward in a 26-3 beatdown. Texans quarterback C.J. Stroud hasn’t thrown an interception this season and adds a familiar weapon outside. Houston acquired wide receiver Marvin Harrison Jr., Stroud’s teammate at Ohio State, in a deal with the Cardinals. The tandem of Nico Collins and Harrison expands the passing game options as Houston deals with a banged-up RB corps. Woody Marks will get the start ahead of David Montgomery. Collins has been a problem for Jacksonville historically with five consecutive games of at least seven receptions and 100 yards. Jacksonville is the first team since the 1969 Cowboys not to allow an opposing running back to rush for more than 40 yards in the first five games of the season. Jaguars quarterback Trevor Lawrence is 5-3 in international games, including last week’s nail-biter against the Eagles in London.
Chicago Bears (3-2) at Atlanta Falcons (2-3)
Sunday, 1 p.m. ET
FanDuel odds: Bears -1.5. Total: 51.5.
Series Rewind: The Bears demolished the Falcons, 37-17, in the last game between these teams in 2023. Four different Bears scored TDs in a matchup of quarterbacks Justin Fields (Bears) and Taylor Heinicke (Falcons).
Tennessee Titans (0-5) at Indianapolis Colts (2-3)
Sunday, 1 p.m. ET
FanDuel odds: Colts -6.5. Total: 44.5.
Series Rewind: The Colts have swept the season series from the Titans three consecutive seasons. Tennessee’s last win was in 2022, a 19-10 victory in which the lone touchdown for the Titans was Andrew Adams’ 76-yard interception return.
The Colts ran into plenty of problems last week in Pittsburgh, specifically 188 yards from scrimmage and two touchdowns from the Steelers’ Jaylen Warren and 235 passing yards and three TD passes from Aaron Rodgers. That was too much to overcome for an Indianapolis offense looking to regain the form that carried the team to an 8-2 start last year. Indianapolis is scoring 24.8 points per game this season (11th in the NFL) but ranks in the bottom half of the league in rushing, passing, total yards and third-down conversion percentage. Although Jonathan Taylor has rushed for 398 yards and six touchdowns in five games, quarterback Daniel Jones hasn’t been quite as efficient. Losing No. 1 wide receiver Alec Pierce hasn’t helped, but Jones has averaged 5.8 yards per attempt. Tennessee could help Jones find the explosive plays the offense has been missing. The Titans are allowing opponents to complete 74% of their passes, a rate surpassed only by the Miami Dolphins’ 76.6%. Tennessee’s offense has been consistently ineffective, averaging a league-low 11.6 points per game. The Titans suffered a 26-3 home loss to the previously winless Houston Texans last week. Tennessee ranks last in total offense, 31st in passing, 27th in rushing and last in average time of possession. Second-year quarterback Cam Ward is averaging 5.8 yards per attempt, the same as Jones. Since the start of the 2024 season, the Titans have lost 33 of 39 games, with four of the defeats coming against the Colts.
New York Jets (2-3) at New England Patriots (3-2)
Sunday, 1 p.m. ET
FanDuel odds: Patriots -7.5. Total: 43.5.
Series Rewind: The Patriots have won 18 of the past 20 meetings.
Wide receiver A.J. Brown could be back for the first time since he hurt his right ankle in a 13-10 Week 1 loss to Seattle. The Patriots are waiting until at least Saturday to gauge whether Brown is fully ready. The Jets snapped a three-game losing streak by beating Cleveland 17-12 last week. The Jets have committed just three turnovers through five games, with quarterback Geno Smith throwing six touchdown passes and no interceptions on 147 attempts. New York wide receiver Garrett Wilson has 31 receptions for 374 yards and three touchdowns. New England cornerback Christian Gonzalez practiced Friday and could be back for another showdown with Wilson. In three head-to-head meetings, Gonzalez limited Wilson to eight receptions for 72 yards on 51 total routes. The Jets have the NFL’s fifth-best scoring defense (19.2 ppg) and will be facing a New England offense that may not have running back TreVeyon Henderson (ankle) or starting left tackle Will Campbell (knee). Henderson and Campbell were both injured against the Raiders, and, like Brown and Gonzalez, were limited in Wednesday’s practice. New England quarterback Drake Maye was intercepted seven times during New England’s first four games, but completed 26 of 34 passes for 374 yards and four touchdowns without an interception during the Patriots’ 45-17 victory over Las Vegas last week.
New Orleans Saints (1-4) at New York Giants (3-1-1)
Sunday, 1 p.m. ET
FanDuel odds: Saints -1.5. Total: 45.5.
Series Rewind: New Orleans has won three consecutive games against the Giants. The all-time series (regular-season games only) between the teams is tied 17-17.
Jameis Winston played four seasons in New Orleans and made 10 starts for the Saints. Now he’s the Giants’ starter after Jaxson Dart’s season-ending knee injury. Winston is 2-0-1 as the starter in potentially his most extended opportunity since being Tampa Bay’s No. 1 quarterback from 2015-19. The Giants leaned more heavily on Winston last week than they had previously and he responded by passing for 326 yards and three touchdowns in leading the team back from a 14-point deficit midway through the fourth quarter to escape Washington with a 27-27 tie. He passed for 254 yards and all three touchdowns after halftime. New York is 3-0 at home, including a 28-20 season-opening win vs. the Cowboys, the only full game Dart played. The Saints played their last three games at home and lost all three, prompting owner Gayle Benson to publicly call the team’s performance “not acceptable to me” and to say she was committed “to making the decisions necessary to improve this team.” After the game Sunday, the Saints will fly to Paris to face the Pittsburgh Steelers on Oct. 25, then have their bye week, meaning they won’t play at home again until Nov. 8 against the Cleveland Browns. During the final nine quarters of the three-game homestand, New Orleans turned the ball over eight times, including three interceptions and two fumbles by Shough.
Baltimore Ravens (4-1) at Cleveland Browns (3-2)
Sunday, 1 p.m. ET
FanDuel odds: Ravens -3.0. Total: 39.5
Series Rewind: Baltimore swept last season’s two meetings and has won the past three. The Browns have started Dillon Gabriel, Joe Flacco, Bailey Zappe, Jameis Winston, Deshaun Watson and Dorian Thompson-Robinson at quarterback in the past six meetings.
Pittsburgh Steelers (3-2) at Tampa Bay Buccaneers (1-4)
Sunday, 1 p.m. ET
Fan Duel odds: Steelers -2.5. Total: 38.5.
Series Rewind: Pittsburgh has won six of the past seven meetings and 10 of 12 all-time. Tom Brady was Tampa Bay’s quarterback the last time these teams met in 2022 and the Buccaneers fell 20-18 after Brady’s two-point conversion throw was broken up by Devin Bush with 4:38 remaining.
Steelers quarterback Aaron Rodgers has thrown three touchdown passes in three consecutive games and completed a season-best 71% of his throws in last week’s 34-22 home win over the Indianapolis Colts. Rodgers has overall passed for 1,234 yards and 10 touchdowns against four interceptions. But the MVP of the offense has been 5-foot-8 Jaylen Warren, who became the sixth player in NFL history to have a rushing touchdown of 50 or more yards and a receiving score of 80 or more yards in the same game. Warren had a career-high 188 scrimmage yards (101 rush, career-best 87 receiving yards) against the Colts and is tied for sixth in the NFL with 410 rushing yards. Steelers star linebacker T.J. Watt continues to excel and has 4.5 sacks and an interception return for touchdown. Undrafted rookie quarterback Jalon Daniels is in line to make his third straight start with Baker Mayfield still recovering from a dislocated right thumb. Mayfield missed practice again Thursday. Daniels guided the Buccaneers to a 24-16 victory over the host Dallas Cowboys on Oct. 8 as he completed 19 of 25 passes for 189 yards and one touchdown. But the biggest contributor was running back Bucky Irving, who had a career-best 165 rushing yards to go with two touchdowns (one rushing, one receiving) to fuel a ground attack that rolled up 241 yards. Irving ranks eighth in the NFL with 406 rushing yards.
Carolina Panthers (2-2) at Philadelphia Eagles (2-3)
Sunday, 1 p.m. ET
FanDuel odds: Panthers -3.5. Total 38.5.
Series Rewind: The Eagles are 9-4 against the Panthers in the regular season. The last four meetings have been decided by six or fewer points, including Carolina’s 22-16 loss at Philadelphia the last time they met in Week 14 in 2024.
Philadelphia has lost three straight games and is playing without Jalen Hurts and possibly Saquon Barkley and DeVonta Smith. Fourth-year backup quarterback Tanner McKee is poised to make just his third NFL start after drawing Week 18 assignments in each of the past two seasons. He will need help from wideouts Darius Cooper (four touchdowns on seven catches this season) and Dontayvion Wicks, who has averaged just 37.7 yards during the losing streak. Coordinator Vic Fangio’s defense ranks 29th in the NFL with only three takeaways, including zero fumble recoveries. The Panthers are rested after a bye week and looking to climb above .500 for the first time this season. Bryce Young leads the NFL with 317 passing yards per game and has thrown three TD passes in each of his past two starts. Running back Chuba Hubbard has had success in the past against Philadelphia with a combined 241 yards from scrimmage and one score in two meetings. The defense ranks 31st against the run (156.5 yards per game).
Arizona Cardinals (1-4) at Los Angeles Rams (2-3)
Sunday, 4:05 p.m. ET
FanDuel odds: Rams -12.5. Total: 51.5.
Series Rewind: The Rams have won three consecutive games over Arizona. Matthew Stafford threw four TD passes in the 37-20 victory to end the 2025 regular season.
Another hard-luck defeat, 37-34 to the Buffalo Bills on Monday night, sends the Rams into Week 6. They’ve played well in the second half of late — LA scored 14 fourth-quarter points to defeat the Philadelphia Eagles 24-20 in Week 4 and forced overtime against the Bills with 20 fourth-quarter points — but a complete game has been fleeting. Matthew Stafford has started to hit his stride after a slow start, completing 74.1% of his passes for 383 yards and three touchdowns against the Bills. He did not throw an interception for the first time this season. Puka Nacua had a career-high 17 receptions that went for 138 yards and a touchdown. Davante Adams had two TD receptions of his own. But the Rams’ kicking game proved costly. They signed Blake Grupe off the New York Jets’ practice squad. In 50 career NFL games over three seasons, mostly for the New Orleans Saints, Grupe has made 81.9% of his field goals. The Cardinals arrive on a four-game losing streak after a 45-21 loss to the Detroit Lions on Sunday. The next day, the Cardinals traded Marvin Harrison Jr. to Houston. Jacoby Brissett completed 61.7% of his passes for 292 yards and three touchdowns, but the Cardinals’ defense gave up 412 total yards, including 163 on the ground. The Lions put the game away with three second-half touchdowns. Arizona now heads back to the Los Angeles area, where they got their season off to what appeared to be a promising start with a 26-14 victory over the Los Angeles Chargers. Arizona gave up an average of 37 points over their last four games and former Rams assistant Mike LaFleur, in his first season coaching the Cardinals, might limit Jeremiyah Love this week because of an ankle injury. The Rams will be without left tackle Alaric Jackson, who was suspended for an altercation after Monday’s loss.
Los Angeles Chargers (0-5) at Kansas City Chiefs (4-0)
Sunday, 4:25 p.m. ET
FanDuel odds: Chiefs -7.5. Total 41.5.
Series Rewind: In their most recent meeting in Week 15 last season, the Chargers completed their first sweep of the Chiefs since 2013, eliminated Kansas City from playoff contention and left Patrick Mahomes with a torn left ACL.
Coming off a bye week, the Chiefs are looking for their fifth 5-0 start since head coach Andy Reid arrived in 2013. Including his 5-0 start with the Eagles in 2004, he can become the third coach in NFL history with six such starts (George Halas, Paul Brown). Mahomes is 10-4 against the Chargers with 28 touchdown passes and eight interceptions. Running back Kenneth Walker is off to a sizzling start with 621 scrimmage yards and six TDs in his first four games with Kansas City, which is playing at home for the first time in nearly a month (Sept. 20 win over the Colts). Travis Kelce needs six catches to pass Cris Carter (1,101) for sixth place in NFL history. Off to their worst start since 2003, the Chargers rank 30th with just 16.8 points per game. Justin Herbert has thrown at least one touchdown — and at least one pick — in every contest this season. Outside linebacker Khalil Mack has 10 sacks in 17 career games against the Chiefs.
Buffalo Bills (4-1) at Las Vegas Raiders (3-2)
Sunday, 4:25 p.m. ET
Fan Duel odds: Bills -5.5. Total: 53.5.
Series Rewind: Buffalo has won the past three meetings and five of seven. The series dates back to 1960 when both teams were part of the American Football League. One forgettable meeting for the Raiders is when the Bills rolled to a 51-3 victory in the 1990 season AFC title game to reach the Super Bowl.
The Bills can move the ball at will and score often but they also can’t seem to slow down opposing offenses. That means a high-scoring affair could be on tap with Buffalo tied for the league lead in scoring at 32.8 points and Las Vegas checking in ninth at 26.4. The Bills stand 28th in scoring defense (28.2) and 30th in total defense (388.6). Monday’s 37-34 overtime road win over the Los Angeles Rams marked the third time this season Buffalo has scored more than 30 points and given up more than 30 in the same game. Running back James Cook III lost two fumbles – one in overtime with the Bills in field-goal range – and that takes the shine off him ranking third in the NFL with 532 rushing yards. Quarterback Josh Allen leads the NFL with eight rushing scores and he rushed for 121 yards against the Rams while passing the ball just 19 times. Receiver DJ Moore (shoulder) and defensive tackle Ed Oliver (knee) both look likely to miss their second consecutive games. The Raiders have dropped two straight contests and were whipped 45-17 by the host New England Patriots last week. Quarterback Kirk Cousins is playing well with 1,269 yards, 12 touchdowns and four interceptions while tight end Brock Bowers had eight receptions for 110 yards and one score against New England. Running back Ashton Jeanty had just 27 yards on 10 carries and has a paltry 3.3 average with 291 rushing yards. The Raiders entered the week tied for the NFL lead in turnover margin (+10).
Dallas Cowboys (2-3) at Green Bay Packers (3-2)
Sunday, 8:20 p.m. ET
FanDuel odds: Packers -1.5. Total: 52.5.
Series Rewind: These non-divisional rivals played to a 40-40 tie in overtime last season in Texas, racking up a combined 925 yards of offense. Including the playoffs, the Cowboys have lost five of their last six games at Lambeau Field.
The Cowboys have alternated wins and losses through five games this season. They are 0-2 in prime time, losing on Sunday night in Week 1 to the Giants and on Thursday night in Week 5 to the Buccaneers. Dak Prescott is just 1-3-1 against Green Bay in the regular season despite racking up 16 total touchdowns (14 passing, two rushing). CeeDee Lamb and George Pickens are facing a Packers defense that ranks No. 5 against the pass, allowing 181 yards per game with more interceptions (seven) than TD passes allowed (six). Running back Javonte Williams has scored 20 touchdowns in his first 21 games with Dallas. Green Bay has bogged down in the red zone with TDs on only nine of 18 trips inside the 20. Jordan Love threw for 337 yards and three scores last season at Dallas, while Christian Watson set a career high with three TD catches in his only prior meeting against the Cowboys back in 2022. Discipline has been an issue for coach Matt LaFleur’s club with 46 penalties for 369 yards.